CERIC Center of Excellence for Research on Inflammation and Cardiovascular disease

CERIC is a Linné Center supported by the Swedish Research Council (Vetenskapsrådet)

 

Next CERIC Seminar

September 2nd CMM Lecture Hall (L8:00)

Speaker: Reinier Boon, Institute of Cardiovascular Regeneration, Goethe University Hospital
Title: Non-coding RNAs and vascular aging
Host: Lars Maegdefessel

CERIC announces

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New postdoctoral researcher initiative with the funding of 13 different post-doctoral positions.

The projects are spread across the research interests of the CERIC faculty and represent a range of investigations into the nature of inflammation and its role in disease.
  • All the projects (click to expand)Open or Close
    1. Magnus Bäck and Per Eriksson

    Inflammation Resolution in Aortic Stenosis and Atherosclerosis

    2. Jesper Haeggström and Craig Wheelock

    The role of lipid mediators in determining macrophage phenotype in relation to immunometabolic processes driving chronic low-grade inflammation

    3. Helena Erlandsson Harris and Birgitta Agerberth

    The Alarmins HMGB1 and LL-37 as mediators of inflammation

    4. Tomas Olsson, Marie Wahren-Herlenius, and Lars Fugger

    Functional impact of genetic polymorphisms in inflammatory disorders

    5. Göran K Hansson and Lars Maegdefessel

    Acetylcholine Release from Choline Acetyltransferase+ T cells in Regulation of Vascular Inflammation

    6. Anders Hamsten and Johan Askling

    Genetic evaluation of the role of PCSK9 in inflammation and cardiovascular disease

    7. Rikard Holmdahl

    Structural analysis of immune response molecules involved in arthritis and atherosclerosis

    8. Stephen Malin

    The pathological and protective functions of B-lymphocytes in autoimmune diseases

    9. Vivianne Malmström

    Analysis of datasets from mass cytometry and from single cell RNA seq of lymphocytes, with special focus on generation of full length B and T cell receptor sequences

    10. Thomas Renné

    Mechanism and therapy for hereditary angioedema type II

    11. Mona Ståhle

    Exploring the molecular and cellular interactions between skin and adipose tissue in Psoriasis

    12. Cecilia Söderberg-Nauclér

    Does virus induced changes in cellular metabolism link inflammation to atherosclerosis?

    13. Jesper Tegnér

    From molecular pathways controlling induction of human T-regulatory cells to their clinical relevance
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CERIC's goal is to be an internationally leading center in chronic inflammation, the pathological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease. For this purpose, we will build on existing, strong research in inflammatory mediators, autoimmunity , chronic inflammatory diseases, and cardiovascular disease at the Karolinska Institutet.

The following research aims will be addressed:



Aim 1: To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease).

Aim 2: To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseases and cardiovascualr diseases

Taken together, these two approaches will allow us to both understand the etiology and pathogenesis of chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronic inflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population.

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