CERIC Center of Excellence for Research on Inflammation and Cardiovascular disease

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Department of Medicine and Center for Molecular Medicine at Karolinska University Hospital, Solna

Phone +46 8 517 762 22

Group members

Faculty


Göran K Hansson, MD, PhD, professor
Magnus Bäck, MD, PhD, senior scientist
Gabrielle Paulsson-Berne, PhD, docent
Zhong-qun Yan, MD, PhD, docent
Anders Gabrielsen, MD, PhD
Daniel Ketelhuth, PhD, assistant professor
Stephen Malin, PhD, assistant professor
Martin Halle, MD, PhD

Postdoctoral fellows


Andrés Laguna, PhD
Daniel Johansson, PhD
John Pirault, PhD
Jonas Persson, MD, PhD
Maria Klement, PhD
Olga Ovchinnikova, PhD
Reiner Mailer, PhD

PhD students


Anton Gisterå, MD
Daniela Strodthoff
Katrin Habir
Konstantinos Polyzos, MD
Leif Söderström, MD
Marcelo Petri, MD
Martin Berg
Tinna Christersdottir
Yajuan Wang, MD
Xiaoying Zhang
Xintong Jiang

Technical & adminstrative staff


Ann Hellström, administrator
Anneli Olsson, lab technician
Ingrid Törnberg, lab technician
Linda Haglund, lab technician
André Strodthoff, research assistant

Göran Hansson

Our research is focused on immune mechanisms in atherosclerosis development. Atherosclerosis is an inflammatory disease. The disease is associated with systemic immune responses and signs of inflammation. Its lesions are filled with immune cells that can orchestrate and effect inflammatory responses. Unstable plaques are particularly rich in activated immune cells, suggesting that they may initiate plaque rupture and atherothrombosis. Experiments in gene-targeted mice have provided mechanistic evidence that immune mechanisms are involved in atherosclerosis.

During recent years, we have seen a rapid increase in understanding of the mechanisms that govern the recruitment, differentiation and activation of immune cells in atherosclerosis. We have identified ApoB100, the protein component of low-density lipoprotein (LDL) as an autoantigen that promotes atherosclerosis, and found that that immune modulation as well as immunization/vaccination can reduce the progression of the disease.

Research interactions with CERIC

  • Chronic inflammation and atherosclerosis – mechanistic studies in experimental models.
  • Inflammatory signaling in atherosclerosis and chronic inflammation – exploration of the transcriptome and proteome in human disease.
  • Immune-metabolic crosstalk - immume modulation of lipid and glucose metabolism.
  • Shared effector molecules in the molecular pathogenesis of chronic inflammatory diseases.

Selected Publications

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

Roland Klingenberg, Norbert Gerdes, Robert M. Badeau, Anton Gisterå, Daniela Strodthoff, Daniel F.J. Ketelhuth, Anna M. Lundberg, Mats Rudling, Stefan K. Nilsson, Gunilla Olivecrona, Stefan Zoller, Christine Lohmann, Thomas F. Lüscher, Matti Jauhiainen, Tim Sparwasser and Göran K. Hansson. Journal Clinical Investigation 123(3):1323-34 (2013).

Transforming Growth Factor–β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17–Dependent Pathway

Anton Gisterå, Anna-Karin L. Robertson, John Andersson, Daniel F. J. Ketelhuth, Olga Ovchinnikova, Stefan K. Nilsson, Anna M. Lundberg, Ming O. Li, Richard A. Flavell, Göran K. Hansson. Science Translational Medicine 5, 196ra100 (2013).

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

Andreas Hermansson, Daniel F.J. Ketelhuth, Daniela Strodthoff, Marion Wurm, Emil M. Hansson, Antonino Nicoletti, Gabrielle Paulsson-Berne, and Göran K. Hansson. Journal of Experimental Medicine 207(5):1081-93 (2010).