CERIC Center of Excellence for Research on Inflammation and Cardiovascular disease

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Rheumatology Unit, Center for Molecular Medicine Karolinska Institutet

Phone +46 8 517 734 31

Group members

Stina Salomonsson, Adjunkt
Vijole Dzikaite, postdoc
Alexander Espinosa, postdoc
Susanna Brauner, PhD student
Aurelie Ambrosi, PhD student
Vilija Oke, PhD Student
Robert Klaunigner, PhD student
Marika Kvarnström, PhD student
Åse Elfving, laboratory engineer

Marie Wahren-Herlenius

We study the role of B lymphocytes in chronic inflammatory diseases with the aim to understand pathogenic processes and identify targets for therapeutic intervention. The conditions we take specific interest in are Sjögren's syndrome and congenital heart block. Our research has a translational approach and involves both basic molecular studies, analysis in experimental models and clinical investigations.

Research interactions with CERIC

  • To dissect genetic contribution to the autoimmune associated congential heart block.
  • To delineate the role of TRIM21/Ro52 in regulation of interferon responses and development of chronic autoimmune disease.

Selected Publications

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

Alexander Espinosa, Valerie Dardalhon, Susanna Brauner, Aurelie Ambrosi, Rowan Higgs, Fransisco J. Quintana, Maria Sjöstrand, Maija-Leena Eloranta, Joan Ní Gabhann, Ola Winqvist, Birgitta Sundelin, Caroline A. Jefferies, Björn Rozell, Vijay K. Kuchroo, and Marie Wahren-Herlenius. Journal of Experimental Medicine 206(8):1661-71 (2009).

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block

Stina Salomonsson, Sven-Erik Sonesson, Lars Ottosson, Saad Muhallab, Tomas Olsson, Maria Sunnerhagen, Vijay K. Kuchroo, Peter Thorén, Eric Herlenius, and Marie Wahren-Herlenius. Journal of Experimental Medicine 201:11-17 (2005).

Mutations in the fibroblast growth factor 10 gene are associated with aplasia of lacrimal and salivary glands (ALSG)

Miriam Entesarian, Hans Matsson, Joakim Klar, Birgitta Bergendal, Lena Olson, Rieko Arakaki, Yoshio Hayashi, Hideyo Ohuchi, Babak Falahat, Anne Isine Bolstad, Roland Jonsson, Marie Wahren-Herlenius & Niklas Dahl. Nature Genetics 37(2):125-7 (2005).