Division of Physiological Chemistry II Department of Medical Biochemistry
Biophysics Karolinska Institute S-171 77 Stockholm, Sweden
Phone +46 8 524 876 30
Fax +46 8 736 0439
Our research centers on performing molecular-based phenotyping to obtain increased knowledge about the mechanisms underpinning disease. Towards that end, we apply a combination of non-targeted metabolomics using high-resolution mass spectrometry (HRMS) and targeted lipidomics to investigate disease mechanisms. Our specific interests center on producing quantitative molecular fingerprints of cardiovascular disease – and identifying metabolite markers of preclinical disease. In addition, we focus on identifying clinical sub-phenotypes of asthma and COPD with the goal of introducing improved methods for diagnosis, prognosis and the prediction of therapeutic responses. These efforts involve the application of an integrated systems-based approach to disease understanding and the development of predictive models in respiratory disease.
Research interactions with CERIC
- Quantitative profiling of lipid mediators (e.g., eicosanoids, sphingolipids, endocannabinoids).
- High resolution mass spectrometry-based metabolomics of inflammatory disease.
- Multivariate statistics methods (MVA) for integration and interrogation of ‘omics-based data structures.
- Investigation of role of oxidative stress upon biology pathways.