CERIC Center of Excellence for Research on Inflammation and Cardiovascular disease

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Department of Medicine, Atherosclerosis Research Unit at the Center for Molecular Medicine
Karolinska University Hospital Solna, Center for Molecular Medicine, Atherosclerosis Research Unit, CMM L8:03, 17176 Stockholm

Phone +46 8 517 732 06

Group members

Ekaterina Chernogubova, PhD (Forskarassistent), Hong Jin, MD, PhD (Senior Postdoctoral Research Fellow), Suzanne M. Eken, MD (PhD student)

Lars Maegdefessel

The discovery of an entirely new method of gene regulation by non-coding antisense RNAs (e.g., microRNAs; long-non-coding-RNAs = lncRNA; Natural Antisense Transcripts = NATs) and their validation crucial modulators of CVD provides new hope for innovative therapy and disease recognition. The most important difference between modulating antisense RNAs (like microRNAs) and the traditional approach of therapy is that traditional drugs have specific cellular targets, whereas microRNAs modulate an entire functional network. With the discovery of antisense RNAs being powerful regulators in a wide variety of diseases, it is only a logical consequence that the possibilities of viewing them as therapeutic and diagnostic entities are being explored.

Our research team utilizes human biobank material (tissue and plasma) of different CVD. Candidate antisense RNAs and their putative gene (mRNA) and protein targets are profiled and detected through different transcriptomic approaches, such as RNA sequencing, microarrays, as well as genetic analyses. Findings from our human profiling studies are extensively investigated in different experimental models of CVD, allowing us to better understand functional aspects of antisense RNA modulation.

Research interactions with CERIC

  • Inflammatory aspects of atherosclerosis and aortic aneurysm disease
  • Role and therapeutic potential of non-coding RNAs (microRNAs, lncRNAs) in atherosclerosis and chronic inflammatory diseases
  • Prognostic and diagnostic biomarker potential of non-coding RNAs in cardiovascular disease
  • Transcriptomic analyses of human biobank material and experimental validation in mechanistic studies of different cardiovascular disease pathologies